She was born in 1822 in South Carolina died 1883 in Missouri.
@PhyllisLayne1 Here are some ways you can get help with your research question:
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Join a Group in Community that focuses on the area where your ancestor lived. Folks in the group will be familiar with available resources. Here's one you might start with: https://community.familysearch.org/en/group/174-southern-states-family-history-research
Visit the FamilySearch Wiki to learn how to do research and what kinds of records are available in the places your ancestor lived. You'll find pages for both South Carolina and Missouri. Just enter the place in the search box to see what articles are available: https://www.familysearch.org/en/wiki/Main_Page
It looks like the earliest confirmed record you have for Nancy is her marriage to James Lane on 29 June 1843 at Owen County, Indiana. I would try to take very small baby steps from this date. Are there tax yearly tax records for this location. If so, are there McIntosh's living in this county? Are there McIntosh's here in the 1840 US Census? If there are, look for land and probate records which may give relationships. You may discover her parents in this way. Just some ideas.